Prelaunch Join the founding cohort
The library
Research informed reading on creatine and the brain. Clear, sourced, and written for people who actually read the studies.
Creatine and lung function: what mouse asthma studies, lung injury models and the only human airway trial actually show, and what it means if you have asthma.
Does creatine cause hair loss? A close reading of the 2009 DHT study, the 2025 hair trial, its critics, and what the evidence still can't tell you.
Creatine for healthy aging, honestly reviewed: what studies show for strength, memory, bone, fertility and heart health, including the null results.
Is creatine safe? Prof. Rick Kreider traces 200 years of research, debunks the cramping, kidney and hair loss myths, and shows where the evidence is strong and where it is still early.
Creatine for women, explained by the researchers who study it: menopause, mood, pregnancy, fertility, teens, dosing, and the kidney myth, checked against the evidence.
Does creatine improve sleep in women? One small trial found young women taking creatine slept longer after strength training. Here is what the evidence shows.
Creatine for women's bone health: what a nutrition scientist's three year experiment and the clinical trials show about creatine, lifting and bone density.
A close reading of the human trials on creatine during sleep loss, what they used, what they measured, and why none of them tested jet lag itself.
How much creatine per day do you really need? Dr. Darren Candow explains why 3 to 5 grams saturates muscle, what bone and brain might need, and what the trials show.
What randomized trials in sedentary adults, older women and sleep deprived volunteers found when creatine was taken without exercise, including the studies that found nothing.
What the five studies that actually tested creatine before versus after training found, and why the answer is less exciting than the marketing.
How creatine works in the body: the creatine kinase and phosphocreatine system explained by Theo Wallimann, with the research on muscle, mitochondria and brain.
Creatine myths on kidneys, steroids, weight gain, fat, and the brain, checked against the actual studies, including the ones that found nothing.
The best time to take creatine for cognitive performance, according to the trials: why daily timing barely matters and what sleep deprivation studies used.
A study by study look at creatine HCl versus creatine monohydrate, covering the head to head trials, the origin of the solubility claim, safety, price and what remains untested.
Creatine vs alpha GPC for focus and memory: what the human trials found, the replication that fell short, the regulator that said no, and the stroke question.
How does creatine work inside your cells? A plain English look at the gene networks, kinases and transporter controls behind creatine, and what the evidence really shows.
Creatine and memory: what human trials measured, which results held up after a correction, and where the evidence is still thin for everyday doses.
How much creatine should older adults take? A clear look at the research on dosage, loading, and training day only creatine for muscle and strength after 50.
Creatine monohydrate vs other forms: Dr. Ralf Jäger explains why buffered, liquid, salt and HCl creatine have not beaten monohydrate in the research.
Why people on dialysis can become creatine deficient, what researchers have studied, and what remains unknown.
Does creatine affect the immune system? A clear look at the research on creatine, inflammation, TNF alpha, and macrophages, and what the evidence really shows.
What research has examined about creatine and the heart, including heart failure studies, safety findings, and early chemotherapy research, and how strong the evidence is.
Creatine and IBD: how gut cells use creatine to power the intestinal barrier, what mouse colitis studies show, and where the human evidence stands so far.
Creatine and vascular health: what early research shows about blood flow, cholesterol, inflammation, and aging arteries, and how strong the evidence is.
What a randomized trial in adults with type 2 diabetes measured when creatine was combined with exercise, how GLUT4 and AMPK fit in, and what remains unproven.
How much creatine for brain health? A leading researcher's doses for muscle, bone and brain, checked against the latest trials and the safety evidence.
What the research actually shows about creatine for endurance runners, including the null results, the recovery data, and who the findings apply to.
What the research actually shows about how creatine gets into the brain, how much oral supplementation changes brain levels, and where the evidence is still thin.
Does creatine loading work after 50? What studies show about megadosing creatine for muscle, memory, kidney labs, and who should skip the loading phase.
What the research actually says about creatine and cognition, and why it does not fit neatly into the nootropic category.
What studies and pediatric guidance actually say about creatine use in teenagers, including the safety data, the gaps, and the body image research.
A close look at what the research actually shows about creatine and water retention, including where the water goes, how long it lasts, and how the picture differs for women.
What the research actually shows about creatine and mental performance when you have not slept, including doses, timelines, and the studies that found nothing.
What creatine is, why pregnancy researchers are studying it, and what the animal and early human evidence does and does not show.
Do vegans and vegetarians need creatine? See what studies show about lower creatine stores on plant based diets, dosing, brain benefits, and safety.
A close look at the preclinical research on creatine and cancer, including the findings that cut both ways and the human trials that came up empty.
A close reading of the actual research on creatine and the brain, including the corrections, null results, and regulatory rulings most articles skip.
Why the most cited meta analysis on creatine and cognition was challenged for double counting, what regulators concluded, and what survives.